Medication reference

How to store Zepbound

How to store the Zepbound pen: refrigerator temperature, time at room temperature, freezing, light and disposal, from the Canadian product monograph.

Last reviewed 2026-11-12 · Information, not medical advice

Key facts

The product monograph says to store Zepbound in a refrigerator at 2°C to 8°C up to the expiration date.
If needed, each pen can be stored unrefrigerated at temperatures below 30°C for up to 30 days.
Do not freeze Zepbound. Do not use Zepbound if frozen.
The instructions for use say to throw away the KwikPen 30 days after first use.

Before first use

The product monograph gives these rules for an unused Zepbound KwikPen:

Store your unused KwikPen in the refrigerator between 2°C and 8°C.
A KwikPen may be used until the expiration date printed on the label if the unused KwikPen has been stored in the refrigerator.
Do not use Zepbound beyond the expiration date.
Protect Zepbound from light.
Keep Zepbound out of reach and sight of children.

After first use and out of the refrigerator

The storage section of the monograph says that each pen can be stored unrefrigerated for up to 30 days, if needed. It sets the limit at temperatures not to exceed 30°C. The patient information words the limit as temperatures below 30°C for up to 30 days.

The instructions for use give these rules for a used KwikPen:

You may store your used KwikPen at room temperature up to 30°C for up to 30 days.
Keep a used KwikPen away from heat and light.
Throw away the KwikPen 30 days after first use, even if the KwikPen has medication left in it.
Throw away the KwikPen after the 4 weekly doses that the pen contains.
Do not store the KwikPen with the needle attached.
Do not store the KwikPen without the pen cap attached.

If it froze, was dropped or looks wrong

The monograph says: do not freeze Zepbound, and do not use Zepbound if frozen.

It gives these rules:

Throw away the KwikPen in a sharps disposal container if it has been frozen.
The KwikPen has glass parts. If you drop the KwikPen on a hard surface, do not use the medicine. Use a new KwikPen for your injection.
Zepbound should not be used if the pen is damaged.
Zepbound should not be used if the solution does not appear clear, free of particles, and colourless to slightly yellow.
Do not use the KwikPen if it is expired or looks damaged.

Disposal

The monograph gives these disposal rules:

Discard your KwikPen after you use it once per week for 4 weeks (4 doses).
Put all used KwikPens into a puncture-resistant (sharps) container, or discard them in accordance with local requirements.
There may be some medicine still left in the KwikPen after the 4 weekly doses. Do not inject the leftover medication.
Put your used pen needles in a sharps disposal container right away after use. Do not throw away loose pen needles in your household trash.
If you do not have a sharps disposal container, you may use a household container of heavy-duty plastic with a tight-fitting, puncture-resistant lid.
The household container must also be upright and stable during use, leak-resistant, and labelled to warn of hazardous waste inside.
When your sharps disposal container is almost full, follow your community guidelines for the right way to dispose of it.
Do not recycle your used sharps disposal container.

Ask a health professional

This page repeats what the Canadian product monograph says. It is not medical advice. Ask your pharmacist or your prescriber what applies to you.